BIT
Bitter Taste Aversion
Class: I - Natural Selection
EPA Total Score: 28 /100
Kim, U. K., & Drayna, D. (2005). Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clinical genetics, 67(4), 275-280.
Abstract: The ability or inability to taste the compound phenylthiocarbamide (PTC) is a classic inherited trait in humans and has been the subject of genetic and anthropological studies for over 70 years. This trait has also been shown to correlate with a number of dietary preferences and thus may have important implications for human health. The recent identification of the gene that underlies this phenotype has produced several surprising findings. This gene is a member of the T2R family of bitter taste receptor genes. It exists in seven different allelic forms, although only two of these, designated the major taster and major non-taster forms, exist at high frequency outside sub-Saharan Africa. The non-taster allele resides on a small chromosomal region identical by descent, indicating that non-tasters are descended from an ancient founder individual, and consistent with an origin of the non-taster allele preceding the emergence of modern humans out of Africa. The two major forms differ from each other at three amino acid positions, and both alleles have been maintained at high frequency by balancing natural selection, suggesting that the non-taster allele serves some function. We hypothesize that this function is to serve as a receptor for another, as yet unidentified toxic bitter substance. At least some of the remaining five haplotypes appear to confer intermediate sensitivity to PTC, suggesting future detailed studies of the relationships between receptor structure and taste function.
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Supporting Evidence
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60/100
Submitted by DJGlass
No one has (yet) rated this source as containing any supporting Phylogenetic evidence for this EPA.
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Supporting Evidence is evidence that suggests that this trait is an Evolved Psychological Adaptation (EPA) - i.e., that it has been shaped by natural selection to solve a particular adaptive problem.
Challenging Evidence
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No one has (yet) rated this source as containing any challenging Phylogenetic evidence for this EPA.
No one has (yet) rated this source as containing any challenging Hunter-Gatherer evidence for this EPA.
Challenging Evidence is evidence that suggests that this trait is not an EPA - e.g., that it is a product of cultural learning or genetic drift, or maybe it does not exist at all. However over each line of evidence for a description.